Paul von Bruns (July 2, 1846–June 2, 1916) was a German surgeon. He was born in Tübingen, and the son of surgeon Victor von Bruns. His father-in-law was Protestant theologian Karl Heinrich Weizsäcker.
In 1882, Bruns became director of the surgical clinic at Tübingen, as well as a full professor at the University. He is remembered for his research in the field of laryngology and his work involving goiters and limb operations.
In 1885, he founded Beiträge zur klinischen Chirurgie (Contributions to Clinical Surgery), and was its editor until his death. With Ernst von Bergmann (1836-1907) and Jan Mikulicz-Radecki (1850-1905), he published the four-volume Handbuch der Chirurgie (Handbook of Surgery).